Nitric oxide (NO)

3/23/00


Click here to start


Table of Contents

Nitric oxide (NO)

Why a separate lecture on NO?

What else is interesting about NO?

From the history: 1620

1772

1800

1867

1914-1918

1977

1980

1987

1998

NO chemistry

NO solubility

Spontaneous decay of NO

Autooxidation of NO

Autooxidation of NO

Reaction with superoxide

Inactivation by hemoglobin

Biosynthesis of NO

NO synthases

NOS I

NOS I

NOS I

NOS II

NOS II

NOS II

NOS III

NOS III

NOS III

Effects of NO on the target tissue

Effects of NO on the target tissue

G kinase in cell membrane

G kinase in endoplasmic reticulum

G kinase in vascular smooth muscle

Fate of cGMP

Pharmacology of NO

Functions of NO: Neurotransmission

Functions of NO: Cytotoxicity

NO in breath

Vascular tone

Endogenous NOS inhibitors

NO in blood vessels

Functions of NO

NO in the kidney

NO inhibits apoptosis

Patophysiology of NO

Septic shock

NO in hypertension

NO in hypertension

NO in hypertension: _

NO and atherosclerosis

NO in therapy

Viagra (sildenafil)

NOates in therapy

Author: Vaclav Hampl

Email: vaclav.hampl@lfmotol.cuni.cz

Home Page: http://physiology.lf2.cuni.cz