Male pseudohermaphroditism caused by androgen resistance
5_-reduktase (type 2) deficiency
conversion of testosterone to dihydrotestosterone
deficiency or defect of androgen receptor gene
mild defects - infertility
complete loss of R function- testicular feminizing syndrome (ext. genitalia female, internal not developed, lack of menstruation)
occurs also in 17_-hydroxylase congenital deficiency