Climacteric Decline of gonad function
mild _ testosterone, slow decline of secondary sexual characteristics
ovaries unresponsive to gonadotropins, function declines, sexual cycle disappear - menopause, caused by decline in the number of primordial follicles
no secretion of progesterone and 17_-estradiol by ovaries, aromatization of androstenedione in the circulation only
atrophy of the uterus and vagina, hot flashes