Estrogens
bind intracellular R, proteosynthesis
38 % of 17_-estradiol bound to GBG (gonadal steroid binding globulin),
60 % to albumin, 2 % free
metabolisation and conversion to glucoronide and sulphate conjugates in liver
excreted in urine, bile (reabsorbtion into bloodstream - enterohepatic circulation)
after menopause declines to low levels
synthetic estrogens (peroral) - resistant to hepatic metabolism - high activity