CURRICULUM VITAE

Current affiliation:

• Professor of Physiology and Pathophysiology
  Charles University Second Medical School, Prague, Czech Republic
• Cardiovascular Research Centre, Prague, Czech Republic

Address:

Department of Physiology Second Medical School Charles University Plzenska 221/130 150 00 Prague 5 - Motol Czech Republic

Telephone: Fax: E-mail: WWW:

+420 257296111 +420 257210995 vaclav.hampl at lf2.cuni.cz http://fyziologie.lf2.cuni.cz/hampl/

Personal details:

Born:		Prague, Czechoslovakia		1962
Marital Status:		Married to Alice		since 1988
Children:		Son Jakub and daughters Marta Caroline and Nicole		1989 , 1993 and 2002

Major research interests:

• Vascular role of nitric oxide
• Pulmonary vascular reactivity
• Oxygen sensing
• Pulmonary hypertension
• Regulation of fetoplacental vasculature

Academic qualifications:

2001		D.Sc. (Normal and Pathological Physiology)   Charles University, Prague Thesis: Role of nitric oxide in the pathogenesis of pulmonary hypertensionin
1990		Ph.D. (Physiology) Czechoslovak Academy of Sciences Thesis: Pulmonary vascular reactivity to hypoxia in the rat
1985		M.S. (Biology) Charles University, Prague Thesis: Thermogenic effect of noradrenaline in skeletal muscle perfused in vitro

Education:

1985-1989		Charles University Prague: School of Pediatrics (postgradual)
1980-1985		School of Natural Sciences

Research and professional experience:

Oct. 2005		Elected rector (to start as of Feb. 2006)	Charles University Prague, Czech Republic
Since 2002 1998-2002 1996-1998		Professor Associate Professor Assistant Professor	Department of Physiology Charles University Second Medical School Prague, Czech Republic
1992-1996 1991-1992		Research Associate Postdoctoral Fellow	Department of Medicine University of Minnesota Medical School Minneapolis, Minnesota
1991		Assistant Professor	Department of Physiology Charles University Second Medical School Prague, Czechoslovakia
1990		Research Associate	Department of Pathophysiology Charles University School of Pediatrics Prague, Czechoslovakia

Professional membership:

Since 2000		Czech Physiological Society
Since 1996		American Heart Association - Council on Cardiopulmonary and Critical Care
Since 1994		American Physiological Society (corresponding member)

Prizes and awards:

2001		Best scientific publication in 2000 Prize Czech Medical Society
1993		John F. Perkins, Jr. Memorial Fellowship Award The American Physiological Society
1991		Charles E. Proshek, M.D. Fellowship in Medicine The Proshek Foundation

Grant support (Principal Investigator):

2005-2007		"Dynamics and mechanisms of the chronic hypoxia-induced alterations in pulmonary and placental circulations" Grant Agency of the Czech Republic #305/05/0672 CSK 6.7 million (~ $ 250,000)
2004-2005		“Pathophysilogy of the effects of chronic hypoxia on the fetoplacental vascular bed” Grant Agency of the Charles University #82/2004/C/2.LF CSK 600,000 (~$ 23,000)
2003		”Does chronic hypoxia elevate vascular resistance in the placenta?” Grant Agency of the Charles University #52/2003/C/2.LF CSK 300,000 (~$ 11,500)
2000-2002		"Calcium release from the sarcoplasmic reticulum in the regulation of the pulmonary circulation during hypoxia" Grant Agency of the Czech Republic #305/00/1432 CSK 2.6 million (~ $ 76,000)
1998-2000		"Hypoxic Fetoplacental Vasoconstriction" Internal Grant Agency of the Czech Ministry of Health # 4538 CSK 1.9 million (~ $ 56,221)
1999		"Mechanism of hypoxic fetoplacental vasoconstriction: role of potassium channels" NATO Science Program Collaborative Research Grant # LST.CLG 975202 BEF 250,000 (~ $ 6,700)
1997-1999		"Therapy for Pulmonary Hypertension" Grant Agency of the Czech Republic # 306/97/0854 CSK 1.25 million (~ $ 37,000)
1994-1996		"Nitric Oxide in Experimental Pulmonary Hypertension" American Heart Association–Minnesota Affiliate Grant-in-aid $ 46,808

Peer reviews of manuscripts for international scientific journals:

• Circulation Research
• American Journal of Pathology
• American Journal of Physiology-Heart and Circulatory Physiology
• American Journal of Physiology-Lung Cellular and Molecular Physiology
• American Journal of Physiology-Cell Physiology
• Journal of Applied Physiology
• European Respiratory Journal
• Life Sciences
• Journal of Laboratory and Clinical Medicine
• Anesthesia and Analgesia
• Physiological Research
• Experimental and Clinical Cardiology

Peer reviews of grant applications:

• The Wellcome Trust
• American Heart Association - Minnesota Affiliate
• Grant Agency of the Czech Republic

• College Development Fund of the Czech Republic

• Grant Agency of the Charles University Prague

Teaching:

Since 1996		Lectures and practicals in physiology (2nd year medical students)
Since 1996		Postgraduate students
Since 1996		Creation and maintenance of teaching resources on the departmental website
1992-1996		Research training of cardiology residents
1987-1991		Practicals in physiology (2nd and 3rd year medical students)

Public activity:

Extracurricular interests and skills:

• Skiing, hiking, white-water canoeing, travel

Primary and review publications: see here on MedLine

Book chapters:

1. Hampl V. , Archer S.L. : The role of endogenous nitric oxide in acute hypoxic pulmonary vasoconstriction. In : W.M. Zapol and K.D. Bloch (editors): Nitric Oxide and the Lung . Marcel Dekker , New York, 1997, pp. 113-135.
2. Hampl V. , Tristani-Firouzi M. , Weir E.K. , Huang J.M.C. , Archer S.L. : Cyclic guanosine monophosphate as a hyperpolarizing factor. In : P.M. Vanhoutte (editor): Endothelium-Derived Hyperpolarizing Factor . Harwood Academic Publishers , Amsterdam, 1996, pp. 153-161.
3. Hampl V. , Walters C.L. , Archer S.L. : Determination of nitric oxide by the chemiluminescence reaction with ozone. In : M. Feelisch and J.S. Stamler (editors): Methods in Nitric Oxide Research . Wiley , Chichester, 1996, pp. 310-318.
4. Archer S.L. , Hampl V. , Huang J.M.C. , Nelson D.P. , Tolarova S. , Shultz P.J. , Weir E.K. : Nitric oxide and cyclic guanosine monophosphate: effects on potassium channels and vascular tone. In : E.K. Weir, S.L. Archer and J.T. Reeves (editors): Nitric Oxide and Radicals in the Pulmonary Vasculature . Futura , Armonk, 1996, pp. 391-413.
5. Hampl V. , Cornfield D.N. , Huang J. , Shultz P.J. , Weir E.K. , Archer S.L. : Nitric oxide. In : A.J. Peacock (editor): Pulmonary Circulation: A Handbook for Clinicians . Chapman and Hall , London, 1996, pp. 99-114.
6. Herget J. , Hampl V. : Pulmonary circulation. In : B.B. Srámek, J. Valenta and F. Klimes (editors): Biomechanics of the Cardiovascular System . Czech Technical University Press , Prague, 1995, pp. 327-336.
7. Archer S.L. , Hampl V. , Huang J. , Cowan N. : The importance of calcium in the regulation of EDRF synthesis in the pulmonary vasculature. In : E.K. Weir, J.R. Hume and J.T. Reeves (editors): Ion Flux in Pulmonary Vascular Control . Plenum , New York, 1993, pp. 223-246
8. Herget J. , Hampl V. : Pulmonary vasculature of adult rats is influenced by perinatal experience of hypoxia. In : J. Widimsky and J. Herget (editors): Pulmonary Blood Vessels in Lung Disease . Karger , Basel, 1990, pp. 70-76.
9. Herget J. , Hampl V. , Palecek F. : Effect of perinatal hypoxia on hypoxic vascular reactivity in adult rats. In : S. Daum (editor): Interaction between Heart and Lung . Thieme , Stuttgart, 1989, pp. 63-66.

Abstracts are listed on my website.