Nondisjunction of the sex chromosomes during gametogenesis

• Klinefelter¥s syndrome (47 XXY and variants)

most common sex chromosome disorder

genitalia of a normal male

dysgenesis of seminiferous tubules

mental retardation

(50% mother, 50 % father)

44 XX _ 22 XX _ 44 XXY _ 22 Y

44 XX _ 22 X _ 44 XXY _ 22 XY

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