H2O2 pulmonary vasoconstriction

ROLE OF HYDROGEN PEROXIDE IN THE MECHANISM OF CHRONIC HYPOXIC PULMONARY HYPERTENSION

Jan Herget a Jiri Wilhelm

HYDROGEN PEROXIDE PRODUCES PULMONARY VASOCONSTRICTION IN ISOLATED SALINE PERFUSED RAT LUNGS.

Arterial bolus injection of 7 mM of H₂O₂ in the preparation of isolated saline perfused rats lungs.

THE VASOCONSTRICTION BY HYDROGEN PEROXIDE IN RATS EXPOSED FOR 3 DAYS TO CHRONIC HYPOXIA IS INCREASED.

Dose pressor response to arterial bolus injections of H₂O₂ in the preparations of saline perrfused lungs isolated from control rats and rats exposed for 3 days to chronic hypoxia ( F_IO₂ = 0.1)

ALVEOLAR MACROPHAGES ISOLATED FROM BRONCHOALVEOLAR LAVAGE OF RATS EXPOSED FOR 3 DAYS OF HYPOXIA ( F_IO₂ = 0.1) PRODUCE MORE H₂O₂ WHEN STIMULATED. AFTER 3 WEEKS OF HYPOXIA THE PRODUCTION OF H₂O₂ IS NORMAL.

Production of H₂O₂ was measured by luminol-dependent chemiluminescence FMLP = N-formyl-methionyl-leucyl-phenylalanine PMA = phorbol-myristate-acetate

Back to the Department of Physiology...

ROLE OF HYDROGEN PEROXIDE IN THE MECHANISM OF CHRONIC HYPOXIC PULMONARY HYPERTENSION

Jan Herget a Jiri Wilhelm

HYDROGEN PEROXIDE PRODUCES PULMONARY VASOCONSTRICTION IN ISOLATED SALINE PERFUSED RAT LUNGS.

THE VASOCONSTRICTION BY HYDROGEN PEROXIDE IN RATS EXPOSED FOR 3 DAYS TO CHRONIC HYPOXIA IS INCREASED.

ALVEOLAR MACROPHAGES ISOLATED FROM BRONCHOALVEOLAR LAVAGE OF RATS EXPOSED FOR 3 DAYS OF HYPOXIA ( FIO2 = 0.1) PRODUCE MORE H2O2 WHEN STIMULATED. AFTER 3 WEEKS OF HYPOXIA THE PRODUCTION OF H2O2 IS NORMAL.

ALVEOLAR MACROPHAGES ISOLATED FROM BRONCHOALVEOLAR LAVAGE OF RATS EXPOSED FOR 3 DAYS OF HYPOXIA ( F_IO₂ = 0.1) PRODUCE MORE H₂O₂ WHEN STIMULATED. AFTER 3 WEEKS OF HYPOXIA THE PRODUCTION OF H₂O₂ IS NORMAL.