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RESEARCH ACTIVITY

 

PHYSIOLOGY OF THE PULMONARY VASCULATURE

Collaborative team of departments of physiology, biochemistry and pathophysiology funded by grants of Czech grant agencies.
See our publications (link to Medline - note that for recent work there are links to full text).

Jan Herget, Martin Vizek, Jana Novotna, Jiri Wilhelm, Vaclav Hampl, Jana Bibova, Tomas Kucera

• Effects of perinatal lung injury
• Chronic hypoxia
• Reconstruction of pulmonary vasculature after the lung injury
• Oxidant stress

Methods available:

• Isolated perfused rat lungs
• Isolated resistance pulmonary arteries myograph
• Measurement of the pulmonary and systemic hemodynamics in the rat (pulmonary artery cathetrization)
• Lung mechanics in the rat
• Lung vessel morphology
• Biochemical measurement of collagen in peripheral lung vessels (gel and capillary electrophoresis)
• Biochemistry of oxidant stress of the lung tissue (chemiluminescence + HPLC)

Some of our findings:

• Long-term consequences for the pulmonary circulation of the perinatal insults
• Respiratory stimulant almitrine mimics hypoxic pulmonary vasoconstriction
• Role of H2O2 in the mechanism of the chronic hypoxic pulmonary hypertension
• Role of nitric oxide in the normal and hypertensive pulmonary circulation
• Treatment of pulmonary hypertension with nitric oxide adducts

 

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